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SPATIO-TEMPORAL ORGANIZATION OF CELL ASSEMBLIES IN NUCLEUS REUNIENS DURING SLOW OSCILLATIONS

David Angulo-Garcia, Maëva Ferraris, Antoine Ghestem, Christophe Bernard, Pascale P Quilichini

The nucleus reuniens (NR) is an important anatomical and functional relay 31 between the medial prefrontal cortex (mPFC) and the hippocampus (HPC). Whether the 32 NR controls neuronal assemblies - a hallmark of information exchange between the HPC 33 and mPFC for memory transfer/consolidation - is not known. Using simultaneous LFP 34 and unit recordings in NR, HPC and mPFC in rats during slow oscillations under 35 anesthesia, we identified a reliable sequential activation of NR neurons at the beginning 36 of UP states, which preceded mPFC ones. NR sequences were spatially organized, from 37 dorsal to ventral NR. Chemical inactivation of the NR disrupted mPFC sequences at the 38 onset of UP states as well as HPC sequences present during sharp-wave ripples. We 39 conclude that the NR contributes to the coordination and stabilization of mPFC and HPC 40 neuronal sequences during slow oscillations, possibly via the early activation of its own 41 sequences.

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