Job Offer: Computational Physicist / Applied Mathematician (VB-Tech | INS)
ABOUT VB-TECH & THE INS
VB-Tech (Virtual Brain Technologies) is a Marseille-based deeptech/medtech startup developing BrainXplore™, the world's first patient-specific digital brain twin platform for personalized neurosurgery. Our flagship product, VEP-1, targets drug-resistant epilepsy through SEEG surgical planning based on computational brain modeling. VB-Tech works hand in hand with the Institut de Neurosciences des Systèmes (INS) — a joint Inserm and Aix-Marseille University research unit on the La Timone campus in Marseille that combines experimental, theoretical and clinical neuroscience to understand the dynamics of the brain in health and disease, notably epilepsy, and is home to The Virtual Brain platform. Our scientific foundation rests on the EPINOV clinical trial (350+ patients, 13 international centers — results under analysis) and over 25 years of R&D led by Prof. Viktor Jirsa (creator of The Virtual Brain and director of the INS). We are also affiliated with EBRAINS, the European research infrastructure for brain science. Through EBRAINS, we contribute to and draw on a shared ecosystem of open data, brain-simulation tools and high-performance computing resources that advance digital neuroscience and brain medicine across Europe.
We are at an exciting inflection point — with clinical partners at UPMC Pittsburgh, UC Davis Health, and BC Children's Hospital Vancouver — and we are growing our core engineering team.
THE ROLE
As a Computational Physicist / Applied Mathematician at VB-Tech, you will work at the heart of our brain modeling engine. You will design, implement and validate the mathematical and computational frameworks that underpin BrainXplore™ — a platform based on physiological brain simulation rather than AI — and contribute directly to advancing personalized neurosurgery planning.
KEY RESPONSIBILITIES
▸ Develop and maintain dynamical and complex systems models of brain activity (whole-brain, patient-specific)
▸ Implement statistical inference and parameter estimation pipelines (Bayesian inference, MCMC, probabilistic programming)
▸ Contribute to the calibration and personalization of brain models from clinical data (MRI, SEEG, EEG)
▸ Explore and integrate neurostimulation modeling where relevant (TI, DBS)
▸ Collaborate closely with neuroscientists and clinicians to validate computational outputs against real patient data
▸ Write clean, tested, production-quality Python code integrated into the BrainXplore™ platform
REQUIRED PROFILE
Education
▸ MSc or PhD in Physics, Applied Mathematics, Computational Neuroscience, or a closely related field
Technical Skills
▸ Dynamical systems and complex systems modeling — neural mass models, bifurcations, network dynamics
▸ Statistical inference and probabilistic programming — Bayesian inference, MCMC, and related frameworks
▸ Python — production-quality scientific computing code
▸ C++ experience is a plus
▸ Familiarity with neurostimulation modeling (TI, DBS) is a plus
TECHNICAL ENVIRONMENT
Python C++ Probabilistic Programming
Bayesian Inference MCMC Dynamical Systems
Neural Mass Models TI / DBS Modeling Brain Simulation
POSITION DETAILS
Location Marseille, France (on-site / hybrid)
Contract CDI or fixed-term — to be discussed
Start date As soon as possible
Level MSc minimum — PhD appreciated
Language French and English required
WHY JOIN VB-TECH?
▸ Work on a clinically deployed, internationally recognized platform with real patient impact
▸ Collaborate daily with world-class neuroscientists including Prof. Viktor Jirsa (creator of The Virtual Brain)
▸ Join a fast-growing deeptech startup at Series A stage, with strong academic and clinical partnerships
▸ Be part of an international team with presence in Marseille, Romania
▸ Contribute to an open science ecosystem (EPINOV trial, EBRAINS, EIC Pathfinder)
To Apply
Send your CV and a brief cover note to: l.otten@vb-tech.fr
Subject: Computational Physicist — Application
VB-Tech | INS
Virtual Brain Technologies | Institut de Neurosciences des Systèmes
Marseille, France · Deep Tech · MedTech · Neuroscience
UMR 1106 – Institut de Neurosciences des Systèmes INS Faculté de Médecine de la Timone
27 Bd Jean Moulin - 13385 Marseille cedex 05. France
Tel : + 33 (0) 4 91 32 42 21 ou 23 | Fax : + 33 (0) 4 91 78 99 14