Joana Cabral, University of Oxford, UK & University of Minho, Portugal | ''Resonance of Local Field Potentials in the Connectome''
Wednesday 5 Dec. 2018 – 15:00, INS Seminar Room, Campus Timone, Red Wing, 5th Floor.
Abstract : I will describe a mechanistic theory for the transient emergence of macroscopic brain rhythms as collective oscillatory modes emerging transiently from reciprocal interactions between local field potentials in the structural skeleton of the Connectome. This mechanism is grounded on theoretical principles governing the formation of frequency-specific coherent attractors in delay-coupled oscillatory systems. Using a reduced phenomenological network model representing interactions between voltage fluctuations generated locally by neuronal ensembles at 40Hz with realistic wiring and propagation times, numerical simulations reveal the transient emergence of spatially-organized collective oscillatory modes peaking between 0.5-30Hz in line with analytic predictions, matching spectral, spatial and temporal signatures of multimodal neuroimaging data.